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Buy Brotizolam online: The influence of Lendormine (diazepine derivative) both on the sleep structure and subjective estimation of sleep was examined in 25 patients at the age of 19-64 years old with neurotic insomnia. The investigation was performed before, during and after 10 days of treatment (0.25 mg before the sleep time). The drug administration resulted in significant improvement of sleep structure that is in sleep duration and efficiency because the drug either promoted falling asleep or increased the second and the forth stages of sleep. Lendormine decreased also the wakening time inside the sleep. The polysomnographic results coincided completely with subjective estimation of sleep by patients themselves after the treatment. The optimal time of therapy didn’t exceed 2 weeks. The drug was well tolerated without any complications. The conclusion is made about high effectiveness of Lendormine in the treatment of patients with insomnia.
Acute pulmonary insufficiency, sleep apnoea syndrome, myasthenia gravis, psychoses, acute narrow-angle glaucoma. Severe hepatic impairment. Pregnancy and lactation.
Paradoxical reactions (e.g. acute hyperexcitability, anxiety, hallucinations, increased muscle spasticity, rage, insomnia, sleep disturbances and stimulation); drowsiness, fatigue, ataxia; sedation and sleepiness, depression, lethargy, apathy, hypoactivity, lightheadedness, disorientation, restlessness, confusion, delirium, headache, slurred speech, dysarthria, syncope, vertigo, tinnitus, dizziness, nervousness, vivid dreams, psychomotor retardation; constipation, diarrhoea, dry mouth, nausea, vomiting, increased salivation; incontinence, dysuria, enuresis, changes in libido, urinary retention, menstrual irregularities; bradycardia, tachycardia, HTN, hypotension, palpitations; visual disturbances, diplopia; urticaria, pruritus, skin rash, dermatitis; hepatic dysfunction (e.g. hepatitis, jaundice), blood dyscrasias (e.g. agranulocytosis, anaemia, thrombocytopenia, eosinophilia).
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Symptoms: Somnolence, confusion, coma, reduced or absent reflexes, resp depression, hypotension. Management: Induce vomiting if the patient is conscious; employ gastric lavage if unconscious. Supportive measures along w/ IV fluids should be employed. Maintain an adequate airway. May administer norepinephrine or metaraminol to treat hypotension or barbiturates if excitation occurs. Flumazenil may be useful as an antidote.
May potentiate the effect of centrally-acting drugs (e.g. neuroleptics, tranquilisers, antidepressants, hypnotics, antiepileptics, antihistamines, analgesics and anaesth).May increase the effect of muscle relaxants.Increased effect w/CYP3A4 inhibitors (e.g. itraconazole, ketoconazole). Decreased effect w/ CYP3A4 inducers (e.g. carbamazepine, efavirenz). Buy Brotizolam online